The present research aimed at revealing the nature of the relationship of organizational loyalty to professional satisfaction. This relationship is still subieet to disagreement and controversy. The research attempted to determine the level of professional satisfaction and organizational loyalty of members of the research sample, and to disclose the nature of the differences between males and females in each of the organizational loyalty and professional satisfaction . The research sample consisted of 305 workers in Al- Sharq Underwear in the city of Damascus, which has a total number of employees represented by 608 individuals which amounted to 50.16%. The researcher set up the first two measures of organizational loyalty and professional satisfaction and were verified to ensure their validity and reliability of using appropriate scientific methods. The most important search results: -A significant relationship at the level of significance 0.01 between organizational loyalty and professional satisfaction (r = 0.640), as shown by the results of multiple regression analysis of factors that contribute to satisfaction, which is indicative of a statistically professional excellence, management style, and monthly income respectively. -A positive association is weak and statistically significant correlation was hound at the level of 0.01 between the professional satisfaction and professional life (r = 0.125). -A positive correlation is statistically significant at the level of 0.01 between organizational loyalty and professional life (r = 0.240). There are no statistically significant differences between males and females in the professional satisfaction. The existence of statistically significant differences at the level of significance 0.01 between male and female in organizational loyalty in favor of males. The researcher also provided some suggestions based on the findings of the research as follows: Paying attention to institutions in general and industry in particular for professional distinction, and monthly income because of their effect on the role of organizational loyalty. The need for the institutions to reconsider the system of incentives and promotions to them. Paying attention by institutions in general and industry institutions in particular to professional satisfaction and organizational loyalty for their employees and monitoring their levels regularly and continuously. Conducting training courses and workshops for clarification of the role of professional satisfaction in work and in facing the problems and difficulties. Also, paying attention to activities that support and contribute to raising the level of professional satisfaction among workers. The need to address the problems that can appear in any institution on scientific and psychological bases.