The current study aimed to explore the relationship of guilt feeling with helplessness feeling among mothers of children with disabilities in Jordan. The sample consisted of (110) mothers of children with disabilities who attend a number of local community associations in the governorates of Jordan kingdom, and they were chosen by the intentional method. To achieve the objectives of the study, the guilt feeling and helplessness scales were developed and their validity and reliability were assured. The study results showed that the level of guilt feeling and helplessness feeling were average, also the result revealed that there was a positive relationship between guilt feelings and helplessness feeling among mothers of children with disabilities. The study recommended conducting several studies similar to the current study that take other variables to identify the pressures faced by mothers of children with disabilities.