This study aims at analyzing biology textbooks required for the secondary stage concerning problems and difficulties resulting from the interaction between science, technology and society (STS). The researcher used an analysis criterion for analyzing the content of books assigned for the secondary stage, in addition to the analytical descriptive approach. The results of research for the biology book of the first secondary class were: A number of (21) problems and difficulties relevant to (6)chief problems were discussed .The rate of these problems reached a moderate one of( ٪47,72). The problems of genetics and human health ,together with the secondary problems related to them are not dealt with. Concerning the book of biology assigned for the second secondary class –scientific section, the following were done: (5) secondary problems relevant to (3)main problems and difficulties were dealt with. The ratio of these problems came to (٪ 11,36). (5) problems and difficulties were not discussed .These problems are hunger, food resources, the defect of environmental balance, exploiting land ,air type and atmosphere and water resources. In connection with the biology book determined for the third scientific secondary class, (8) secondary problems connected with (3) chief problems were discussed. The rate of these problems reached (٪18,18); (5) problems were not discussed. These problems are the defect of environmental balance ,exploiting land, type of air and atmosphere, water resources and pollution.