The purpose of this study was to compare between Syrian and British University Students in five specific domains of satisfaction of life included in Multidimensional Students, Life Satisfaction Scale (MSLSS) which are: family, friends , school , life environment and self, in the light of gender and academic specialization. In order to achieve the objectives of the study MSLSS was administered to a sample of 616 Syrian undergraduates selected from Damascus University and 443 British undergraduates from Edinburgh University.Applying the analysis of variance, significant differences were found between Syrian and British students in four domains. That is, Syrian students gave the higher degree to the domains of friends and self, whereas British students gave the higher degree to the domains of school and life environment. Significant differences were also found between humanities and science students in domains of family ( in favour of science students) and school (in favour of humanities students), and between male and female students in the domain of friends (in favour of female students) .It is recommended that more research is needed to conduct cross-cultural comparisons between Syrian students and students of other nationalities and cultures. The satisfaction of life scale is worthy of further investigation in Arabic context.