The present study aimed to investigate the effectiveness of a proposed educational program on developing the skill of designing and developing interactive e-books among the female students of E-learning diploma. It utilized the experimental approach to verify the study hypotheses. The sample consisted of (22) students. It also applied an achievement test to measure the cognitive aspect and an observation card to measure the performative aspect of designing and developing interactive e-books skills. The results showed that the effectiveness of the proposed educational program in developing the skills of designing and developing interactive E-Books among students at Princess Nourah Bint Abdulrahman University. The study recommended the need to benefit from interactive e-books that should be utilized in university education for developing e-learning.